Di-tert-butyl (2S)-5-oxopyrrolidine-1,2-dicarboxylate

Di-tert-butyl (2S)-5-oxopyrrolidine-1,2-dicarboxylate - Names and Identifiers

Name	di-tert-butyl (2S)-5-oxopyrrolidine-1,2-dicarboxylate
Synonyms	LogP BOC-S-PYR-OTBU BOC-L-PYR-OTBU BOC-(2S)-PYROGLUT-TBU (S)-N-BOC-PYROGLUTAMIC ACID TERT-BUTYL ESTER Di-tert-butyl (2S)-5-oxopyrrolidine-1,2-dicarboxylate DI-TERT-BUTYL (2S)-5-OXOPYRROLIDINE-1,2-DICARBOXYLATE di-tert-butyl (2S)-5-oxopyrrolidine-1,2-dicarboxylate 1,2-di-tert-butyl (2S)-5-oxopyrrolidine-1,2-dicarboxylate (S)-N-α-T-BUTYLOXYCARBONYL-PYROGLUTAMIC ACID T-BUTYL ESTER (S)-N-Alpha-T-Butyloxycarbonyl-Pyroglutamic Acid T-Butyl Ester (S)-N-ALPHA-T-BUTYLOXYCARBONYL-PYROGLUTAMIC ACID T-BUTYL ESTER (S)-N-ALPHA-TERT-BUTYLOXYCARBONYL-PYROGLUTAMIC ACID T-BUTYL ESTER
CAS	91229-91-3
InChI	InChI=1/C14H23NO5/c1-13(2,3)19-11(17)9-7-8-10(16)15(9)12(18)20-14(4,5)6/h9H,7-8H2,1-6H3/t9-/m0/s1

Di-tert-butyl (2S)-5-oxopyrrolidine-1,2-dicarboxylate - Physico-chemical Properties

Molecular Formula	C14H23NO5
Molar Mass	285.34
Density	1.138±0.06 g/cm3(Predicted)
Melting Point	55.0 to 59.0 °C
Boling Point	390.7±35.0 °C(Predicted)
Flash Point	190.067°C
Vapor Presure	0mmHg at 25°C
pKa	-4.28±0.40(Predicted)
Storage Condition	Keep in dark place,Sealed in dry,Room Temperature
Refractive Index	1.485

Di-tert-butyl (2S)-5-oxopyrrolidine-1,2-dicarboxylate - Introduction

di-tert-butyl (2S)-5-oxopyrrolidine-1,2-dicarboxylate is a compound whose chemical formula is C14H23NO6. The following is a description of the properties, uses, preparation and safety information of the compound:

Nature:
-Appearance: di-tert-butyl (2S)-5-oxopyrrolidine-1,2-dicarboxylate is a colorless to white crystalline solid.
-Solubility: It is soluble in organic solvents such as ethanol, methanol and dimethyl sulfoxide.
-Melting point: The compound melts at about 104-105°C.

Use:
di-tert-butyl (2S)-5-oxopyrrolidine-1,2-dicarboxylate is a commonly used amino acid derivative, often used as a reagent in organic synthesis. It can be used to synthesize biologically active compounds, such as drugs and polymer materials.

Method:
The preparation of di-tert-butyl (2S)-5-oxopyrrolidine-1,2-dicarboxylate is usually carried out by the following steps:
1. Dissolve pyroglutamic acid tert-butyl ester in dry dimethyl sulfoxide.
2. An appropriate amount of N,N'-dihydroxyethyl isopropanamide was added and the reaction mixture was cooled to below 0°C.
3. Add di-tert-butyl carbonate slowly while maintaining the temperature of the reaction mixture below 0°C.
4. After completion of the reaction, the reaction mixture was added to water to produce a solid precipitate of di-tert-butyl (2S)-5-oxopyrrolidine-1,2-dicarboxylate.
5. The final product was obtained by the steps of crystallization, filtration and drying.

Safety Information:
di-tert-butyl (2S)-5-oxopyrrolidine-1,2-dicarboxylate should be used and handled in accordance with safe practices to avoid exposure to skin, eyes and inhalation. In addition, it should be stored in a dry, cool place and away from fire and oxidants. For specific safety information, refer to the Chemical Safety Data Sheet (MSDS) or the relevant information provided by the supplier.

Last Update：2024-04-09 20:52:54